【 文献重点摘要 】
 

Background

For periorbital rejuvenation, injection of botulinum toxin A (BoNT/A) is known to improve both static as well as dynamic wrinkles. A microneedle fractional radiofrequency (MFR) device was recently developed and is a novel and promising tool.

Objective

This study compares the effects of these two treatment modalities on periorbital static wrinkles and lines.

Methods

Twelve healthy women aged 20–59 years with periorbital wrinkles participated in this study. Each patient received one session of intradermal injection of BoNT/A on the left periorbital area and three sessions of MFR on the right. Clinical improvement, skin elasticity and subjective satisfaction were evaluated at every visit (baseline, 3, 6 and 18 weeks).

Results

BoNT/A injection showed superior effects at 3 and 6 weeks. However, the MFR device showed better improvement at 18 weeks. In skin biopsies, the expression of procollagen 3 and elastin was increased on the MFR side compared to the untreated skin and the BoNT/A injection side. The patient satisfaction surveys at 3 weeks showed better satisfaction on the BoNT/A treatment side compared to the MFR treatment side. At 18 weeks, there were no significant differences in patient satisfaction between the two sides.

Conclusion

BoNT/A injection rapidly improved periorbital wrinkles, but the effect decreased up to week 18. Compared to BoNT/A injection, MFR therapy showed gradual and long-term improvement in periorbital rejuvenation.

背景

对于眼眶周围年轻化，已知注射A型肉毒毒素(BoNT/A)既可以改善静态皱纹，也可以改善动态皱纹。微针分数射频(MFR)装置是最近发展起来的一种新的、有前途的工具。

目的

比较两种治疗方法对眶周静止性皱纹的影响。

方法

12名20~59岁患有眶周皱纹的健康女性参加本次研究。每例患者左侧眶周皮内注射BoNT/A 1次，右侧皮内注射MFR 3次。在每次就诊时(基线、3、6和18周)评估临床改善情况、皮肤弹性和主观满意度。

结果

BoNT/A注射剂在3周和6周均有较好的疗效。然而，MFR装置在18周时显示出更好的改善。在皮肤活检中，与未经处理的皮肤和BoNT/A注射侧相比，MFR侧的前胶原3和弹性蛋白的表达增加。3周后的患者满意度调查显示，与MFR治疗侧相比，BoNT/A治疗侧的满意度更高。在18周时，双方的患者满意度没有显著差异。

结论

BoNT/A注射可迅速改善眶周皱纹，但至18周时效果下降。与BoNT/A注射相比，MFR治疗对眶周皱纹的改善具有渐进性和长期性。