首页 / 国际医美文献/ 磨皮 / Recovery of Skin Barrier After Stratum Corneum Removal by Microdermabrasion
  • 3549人
  • 分享
    收藏

Recovery of Skin Barrier After Stratum Corneum Removal by Microdermabrasion

价格 19.90
学习有效期 长期有效

简介

【 文献重点摘要 】

 

Microdermabrasion is widely used as a non-invasive cosmetic technique that has recently been adapted to selectively remove stratum corneum to increase skin permeability for transdermal drug delivery. This study measured the kinetics of skin barrier recovery after stratum corneum removal using microdermabrasion in hairless guinea pigs. The skin was abraded at two sites on each animal, one of which was allowed to recover under occlusion while the other remained non-occluded. Histological measurements showed that skin barrier properties to sulforhodamine B largely recovered within 12 h, and the stratum corneum appeared largely reformed within 24 h for both occluded and non-occluded skin. Skin electrical resistance measurements showed significant recovery of the skin barrier within 24 h. We conclude that transdermal drug delivery may occur for up to 12 h after microdermabrasion in guinea pigs; however, humans will probably have a longer recovery time due to expected slower skin healing rates.

 

KEY WORDS

microdermabrasion; skin permeability; skin repair kinetics; stratum corneum barrier function; transdermal drug delivery

 

微晶磨皮作为一种非侵入性美容技术被广泛使用,最近被用于选择性去除角质层,以增加经皮给药的皮肤渗透性。这项研究测量了无毛豚鼠使用微晶磨皮去除角质层后皮肤屏障恢复的动力学。每只动物的皮肤在两个部位磨损,其中一个部位在咬合下恢复,而另一个部位保持不咬合。组织学测量表明,皮肤对硫罗丹明B的屏障性能在12小时内基本恢复,并且角质层在24小时内似乎在封闭和非封闭皮肤上都有很大程度的改善。皮肤电阻测量显示皮肤屏障在24小时内显著恢复。我们得出结论,豚鼠微晶磨皮后,经皮给药可达12小时;然而,由于预期的皮肤愈合速度较慢,人类可能会有较长的恢复时间。

 

关键字

微晶磨削;皮肤渗透性;皮肤修复动力学;角质层屏障功能;透皮给药

题库
暂无绑定的题库哦~

学习目录

学员评价

暂无评价哦~
授课老师

DMCAS学习顾问

资料研究员

猜你想学