【 文献重点摘要 】

Microneedling (MN) is a novel therapeutic modality in dermatology. Through physical trauma from needle penetration, MN induces a wound healing cascade with minimal damage to the epidermis. This allows for enhancement in the absorption of mainstay topical therapies across the thick stratum corneum. MN has become increasingly utilized over the last several years as it is a relatively simple procedure that is cost-effective, well tolerated, and offers both cosmetic and therapeutic benefits. The ability to treat localized areas of disease has led to numerous studies gauging its potential in focal diseases of inflammation, dyschromia, and photodamage. This review discusses the principles and evidence behind the expanding applications of MN. It has shown promising results as an adjuvant therapy for enhanced drug delivery in the treatment of atrophic scars, alopecia, actinic keratoses, and disorders of pigmentation such as melasma. The efficacy in treatment of vitiligo remains limited. Overall, the procedure has few adverse sequelae compared to other therapies, is highly efficacious, and is a viable resurfacing option for skin of color. Future research is needed to determine the frequency, interval, and specific device settings that foster optimal results. Additionally, large controlled trials are needed to shed light on the utility of MN as an evidence-based regimen for the treatment of various dermatologic conditions.

Keywords

microneedling, scars, acne, alopecia, hyperpigmentation, actinic keratosis

微粉化是皮肤病学中一种新的治疗方法。通过针刺造成的物理创伤，锰诱导伤口愈合级联，对表皮的损伤最小。这使得厚角质层的主要局部疗法的吸收得到增强。在过去的几年里，锰的使用越来越多，因为它是一种相对简单的方法，具有成本效益，耐受性好，并提供美容和治疗的好处。治疗局部疾病的能力已经导致了许多研究，评估其在炎症、色素异常和光损伤等局灶性疾病中的潜力。这篇综述讨论了移动网络应用扩展背后的原理和证据。在治疗萎缩性瘢痕、脱发、光化性角化病和色素沉着疾病如黄褐斑中，它作为增强药物递送的辅助疗法显示出有希望的结果。白癜风的治疗效果仍然有限。总的来说，与其他疗法相比，该手术几乎没有不良后遗症，非常有效，是一种可行的有色皮肤表面重建选择。未来的研究需要确定频率、间隔和特定的设备设置，以获得最佳结果。此外，需要大型对照试验来阐明锰作为治疗各种皮肤病的循证疗法的实用性。

关键词

微粒化，疤痕，痤疮，脱发，色素沉着过度，光化性角化病