A New Minimally Invasive Mesotherapy Technique for Facial Rejuvenation
【 文献重点摘要 】
Introduction
This study describes a pivotal clinical trial of a new minimally invasive mesotherapy technique for facial rejuvenation.
Methods
The authors utilized two formulations: formulation A with hyaluronic acid, vitamins, amino acids, minerals, coenzymes, and antioxidant substances; formulation B with hyaluronic acid and idebenone. Fifty participants were enrolled in the study and divided in two groups. Group 1 (50–65 years) treated with formulation A. Group 2 (35–50 years) treated with formulation B. The groups underwent four sessions of mesotherapy involving multiple injections. Treatment was conducted at 15 day intervals. All participants had pre- and posttreatment photographs. Punch biopsies were taken from randomly selected participants, baseline and after 6 weeks, and stained for interleukin (IL)-6, IL1β, matrix metalloproteinase (MMP)-1, and collagen 1. Clinical evaluation was based on the Global Aesthetic Scale (GAIS) and on the Wrinkle Severity Rating Scale (WSRS).
Results
The results produced were statistically analyzed and resulted in a significant and long-lasting effect on facial rejuvenation. Evaluation of photographs at 0, 1, and 2 months revealed significant clinical improvement: brightness, texture, and firmness of the skin. The analysis of the GAIS and WSRS scores in the two groups demonstrated statistically significant results after 2 months. The biopsies taken from randomly selected participants at baseline and after 3 months showed a decrease in IL1β, IL-6, and MMP1, and an increase in collagen 1.
Conclusion
The new minimally invasive mesotherapy technique described can improve the clinical appearance of the skin in different age groups.
Keywords
Biorevitalization; Cosmetic dermatology; Facial rejuvenation; Fillers; Mesotherapy; Soft-tissue augmentation
前言
本研究描述了一种新的面部年轻化微创中胚层疗法技术的关键临床试验。
方法
采用透明质酸、维生素、氨基酸、矿物质、辅酶和抗氧化剂组成的制剂A和含有透明质酸和艾地苯酮的制剂B。50名参与者参加了这项研究,并被分成两组。第1组(50-65岁)用配方A治疗;第2组(35-50岁)用配方B治疗。治疗间隔15天进行。所有参与者都有治疗前和治疗后的照片。分别于基线和6周后随机抽取穿孔活检标本,进行白细胞介素-6(IL-6)、白细胞介素1β(IL1β)、基质金属蛋白酶-1(MMP)-1和胶原1的染色。临床评价基于全球美学评分和皱纹严重程度评定量表(WSRS)。
结果
统计分析结果表明,美容美容效果显著且持久。在0个月、1个月和2个月时对照片的评估显示出显著的临床改善:皮肤的亮度、质地和坚固性。两组治疗2个月后的GAIS评分和WSRS评分比较。随机选择的参与者在基线和3个月后的活组织检查显示,白细胞介素1β((IL1β)、白细胞介素-6(IL-6)和基质金属蛋白酶1(MMP1)降低,而胶原1增加。
结论
所描述的微创中胚层疗法新技术可改善不同年龄组皮肤的临床外观。
关键词
生物活化;美容皮肤科;面部年轻化;填充物;中胚层疗法;软组织增大术