【 文献重点摘要 】

Background

Combination therapies used to treat the photoaged skin have become more popular as studies demonstrate greater efficacy and improved clinical outcomes compared to single treatment modalities.

Objectives

To evaluate the safety and effectiveness of treating the lateral canthal rhytide complex with a Jessner’s and 35% TCA peel with and without pretreatment with BTX-A.

Methods

Twenty-six subjects with Fitzpatrick skin types I -III were randomized to receive treatment of their lateral canthal rhytide complex with a Jessner’s and 35% TCA peel with or without pretreatment with BTX-A. A single blinded dermatologist assigned a lateral canthal wrinkle score of subjects’ at baseline and week 8-10.

Results

Comparison between the two treatment groups demonstrated that the group receiving combination treatment had significantly greater improvement in wrinkle reduction as compared to the group only receiving the chemical peel (P =0.002). In addition, there was no significant association between skin type and treatment groups (P = 0.11).

Conclusions

These findings suggest that treating the lateral canthal rhytide complex with a combination of BTX-A followed by Jessner’s and 35% TCA peel is more effective than chemical peel alone. These results are independent of skin type and demonstrate an additional treatment strategy for lateral canthal rhytides.

背景

联合疗法用于治疗光老化皮肤已经变得越来越流行，因为研究表明，与单一治疗方式相比，联合疗法具有更好的疗效和更好的临床结果。

目的

评价用Jessner‘s和35%TCA剥脱术联合BTX-A预处理和不联合BTX-A预处理治疗外侧泪小管复合体的安全性和有效性。

方法

26例Fitzpatrick皮肤I-III型患者随机接受Jessner‘s和35%TCA去皮加BTX-A预处理或不加BTX-A预处理的治疗。一位单盲皮肤科医生在基线和第8-10周给受试者分配了侧眼角皱纹评分。

结果

两组间比较，联合治疗组的除皱效果明显优于单纯化学去皮组(P=0.002)。此外，皮肤类型与治疗组之间无显著相关性(P=0.11)。

结论

本研究结果提示BTX-A联合Jessner‘s和35%TCA剥脱术治疗外侧泪小管复合体较单用化学剥脱术更有效。这些结果与皮肤类型无关，并证明了另一种治疗外侧眼角皱纹的策略。