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使用A型肉毒毒素预防面部瘢痕扩大
Use of Botox Type A to Prevent Widening of
简介
【 文献重点摘要 】
Background
Wounds of the face, especially those lying perpendicular to the lines of Langer, are known to heal poorly with conspicuous scarring. Different methods have been tried to tackle this problem, including corticosteroid injections, irradiation, ultrasound, silicone applications, and many others. However, as expected, their effects were far from satisfactory, because they do nothing to alleviate the underlying pathologic process, which is the distracting effect of muscle pull on immature collagen.
Methods
In 40 patients with ugly scars of the face, botulinum toxin was used to induce temporary paralysis of the muscles during revision surgery, thus minimizing tension on healing wound edges until the collagen could mature.
Results
Using both objective and subjective assessment scales, 90 percent of patients ended up with an improved outcome. This new technique has been proven effective in primates and in this study was shown to be as effective in humans, yielding results superior to those of any other treatment modality.
Conclusion
In view of the results of this study, it is considered worthwhile to offer patients with ugly scars of the face botulinum toxin injections simultaneous with revision surgery.
背景
面部的伤口，尤其是那些垂直于兰格线的伤口，愈合不良，有明显的疤痕。已经尝试了不同的方法来解决这个问题，包括皮质类固醇注射、辐射、超声波、硅酮应用以及许多其他方法。然而，正如所料，它们的效果远非令人满意，因为它们无助于缓解潜在的病理过程，即肌肉牵拉对未成熟胶原蛋白的分散作用。
方法
对40例面部瘢痕丑陋的患者，在翻修术中使用肉毒杆菌毒素诱导肌肉暂时麻痹，从而使愈合伤口边缘的张力最小化，直到胶原蛋白成熟。
结果
使用客观和主观评估量表，90%的患者最终获得了改善的结果。这项新技术已被证明在灵长类动物中有效，并且在这项研究中被证明在人类中同样有效，产生的结果优于任何其他治疗方式。
结论
鉴于本研究的结果，在翻修手术的同时注射肉毒杆菌毒素被认为是值得的。
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