【 文献重点摘要 】
 

Background: Injectable devices offer an attractive alternative to surgical cosmetic rejuvenation. Many injectable products are biocompatible but demonstrate varying levels of durability, ranging from temporary to permanent. Product duration is determined, in part, by its mode of operation. Passive fillers, such as collagen, generally add volume through mass, whereas other injectables, such as poly-L-latic acid (PLLA), rely on a foreign-body response in which endogenous collagen production by fibroblasts is thought to generate new volume.

Objective: To review the use of injectable PLLA, specifically regarding optimal injection technique that can reduce adverse events (AEs) and enhance out comes.

Results: PLLA has been used extensively to correct HIV-related facial lipoatrophy, with effects lasting for up to 2 years. The efficacy and safety of PLLA can be influenced by correct product reconstitution, dilution, and administration. Undesired AEs, such as papules and nodules, may result from incorrect reconstitution, uneven product distribution in the suspension, imprecise injection technique (superficial injection), or lack of posttreatment massage.

Conclusion: Administration of PLLA with optimal techniques can help enhance treatment effect while simultaneously minimizing AES.

背景：可注射装置为外科美容年轻化提供了一种有吸引力的选择。许多注射产品是生物相容的，但表现出不同程度的耐久性，从暂时性到永久性不等。产品的持续时间在一定程度上是由其操作模式决定的。被动填充物，如胶原，通常通过质量增加体积，而其他注射剂，如聚左旋乳酸(PLLA)，依赖于异物反应，在异物反应中，成纤维细胞产生内源性胶原被认为能产生新的体积。

目的：综述注射用聚乳酸(PLLA)的应用，特别是能减少不良事件(AEs)、提高疗效的最佳注射技术。

结果：PLLA已被广泛用于矫正HIV相关性面部脂肪萎缩，效果可达2年。正确的产品重组、稀释和给药可以影响PLLA的有效性和安全性。不受欢迎的不良反应，如丘疹和结节，可能是由于重建不正确、悬浮液中产品分布不均匀、注射技术不精确(表面注射)或缺乏治疗后按摩所致。

结论：采用最佳给药技术可提高治疗效果，同时最大限度地降低AES。