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Development and Validation of a Photonumeric Scale for Evaluation of Infraorbital Hollows

Donofrio Lisa

价格 19.90
学习有效期 长期有效

简介

【 文献重点摘要 】

 

BACKGROUND

A validated scale is needed for objective and reproducible comparisons of infraorbital hollows (i.e., tear troughs) before and after treatment in practice and clinical studies.

 

OBJECTIVE

To describe the development and validation of the 5-point photonumeric Allergan Infraorbital Hollows Scale.

 

METHODS

The scale was developed to include an assessment guide, verbal descriptors, morphed images, and real subject images for each grade. The clinical significance of a 1-point score difference was evaluated in a review of image pairs representing varying differences in severity. Interrater and intrarater reliability was evaluated in a live-subject validation study (N = 297) completed during 2 sessions occurring 3 weeks apart.

 

RESULTS

A score difference of ≥1 point was shown to reflect a clinically significant difference (mean [95% confidence interval] absolute score difference, 0.90 [0.79–1.02] for clinically different image pairs and 0.33 [0.19–0.46] for not clinically different pairs). Intrarater agreement between the 2 validation sessions was substantial (mean weighted kappa = 0.79). Interrater agreement was substantial during the second rating session (0.70, primary end point).

 

CONCLUSION

The Allergan Infraorbital Hollows Scale is a validated and reliable scale for physician rating severity of hollowing in the infraorbital area.

 

背景

在实践和临床研究中,需要一个有效的量表对治疗前后的眶下窝(即泪沟)进行客观和可重复的比较。

 

目的

描述五点光数字阿勒根眶下窝量表的发展和验证。

 

方法

该量表包括每个年级的评估指南、语言描述、变形图像和真实受试者图像。在对代表不同严重程度差异的图像对的审查中,评估了1分评分差异的临床意义。评分者间和评分者内的可靠性在一项现场受试者验证研究(297人)中进行评估,该研究在间隔3周的2次会议中完成。

 

结果

显示≥1分的评分差异反映了临床显著性差异(平均[95%置信区间]绝对评分差异,临床不同图像对为0.90[0.79–1.02],非临床不同图像对为0.33[0.19–0.46])。两次验证会议之间的评分者内一致性显著(平均加权kappa = 0.79)。在第二次评分期间,评分者之间的一致程度很高(0.70,主要终点)。

 

结论

Allergan眶下凹量表是一种有效、可靠的医生评定眶下区凹陷严重程度的量表。

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