【 文献重点摘要 】
 

Background: Over the last few years, injectable soft-tissue fillers have become an integral part of cosmetic therapy, with a wide array of products designed to fill lines and folds and revolumize the face.

Methods: This review describes cosmetic fillers currently approved by the Food and Drug Administration and discusses new agents under investigation for use in the United States.

Results: Because of product refinements over the last few years—greater ease of use and longevity, the flexibility of multiple formulations within one line of products, and the ability to reverse poor clinical outcomes—practitioners have gravitated toward the use of biodegradable agents that stimulate neocollagenesis for sustained aesthetic improvements lasting up to a year or more with minimal side effects. Permanent implants provide long-lasting results but are associated with greater potential risk of complications and require the skilled hand of the experienced injector.

Conclusions: A variety of biodegradable and nonbiodegradable filling agents are available or under investigation in the United States. Choice of product depends on injector preference and the area to be filled. Although permanent agents offer significant clinical benefits, modern biodegradable fillers are durable and often reversible in the event of adverse effects.

背景：在过去的几年里，可注射软组织填充物已经成为美容治疗中不可或缺的一部分，设计了一系列产品来填充线条和褶皱，并使面部旋转。

方法：本综述描述了美国食品和药物管理局(FDA)目前批准的化妆品填充剂，并讨论了正在研究中的在美国使用的新制剂。

结果：由于过去几年产品的改进-更易于使用和寿命更长，一条产品线内多种配方的灵活性，以及扭转不良临床结果的能力-从业者已被吸引到使用可刺激新胶原形成的生物降解剂，以获得持续一年或更长时间的美学改善，副作用最小。永久性植入物提供了长期的效果，但与更大的潜在并发症风险相关，并且需要有经验的注射者熟练的手。

结论：在美国有多种可生物降解和不可生物降解的填充剂可供选择或正在研究中。产品的选择取决于喷油器的偏好和要填充的区域。虽然永久性填充剂提供了显著的临床益处，但现代的可生物降解填充物是耐用的，而且在出现不良反应时往往是可逆的。