【 文献重点摘要 】
 

Background

Improving skin texture in the face is a popular procedure in older women. Procedures using stabilized hyaluronic acid (S-HA) to improve skin texture should be distinguished from volumizing procedures. The intradermal injection of S-HA has many benefits, such as being safe from embolism, having a high ease of injection, and leading to dramatic improvements in skin texture and hydration. HA is the main component of the extracellular matrix and dermal hydration can help counteract the effects of aging. When the dermis is well hydrated using S-HA, it looks healthier, and this effect can last for more than half a year. Various intradermal injection techniques have been reported, such as manual injection, the blanching technique, and using an automatic injector with multiple needles.

Method

The dermis can be treated with microdroplets (0.001 cc) of S-HA at a thousand of injection sites using an injector. This unique injection method was Named "Microhyaluronicacid" by the author, based on an analogy with Microbotox5. The author invented a unique injection solution in which S-HA is mixed with botulinum toxin A; this solution has been used for dermal hydration and skin rejuvenation since 2009. To reduce the risk of creating a dermal lump, polydensified monophasic HA and automatic injector were used. Microhyaluronicacid and Microbotox were combined by the author.

Results

In 50 patients, changes in fine wrinkles were measured using a dermascope, and dermal hydration was measured by transepidermal water loss and stratum corneum hydration levels.

Conclusion

The changes of transepidermal water loss and stratum corneum hydration were statically significant at 4 and 8 weeks.

背景

改善面部皮肤质地在老年女性中很受欢迎。使用稳定的透明质酸(S-HA)改善皮肤质地的手术应该与充盈手术相区别。皮内注射S-HA有许多优点，例如不会发生栓塞，注射非常容易，并能显著改善皮肤质地和水合情况。透明质酸是细胞外基质的主要成分，真皮水合可以帮助抵消衰老的影响。当真皮使用S-HA保湿良好时，它看起来更健康，这种效果可以持续半年以上。已经报道了各种皮内注射技术，例如手动注射、漂白技术和使用带有多个针的自动注射器。

方法

使用注射器在1000个注射部位用S-HA微滴(0.001毫升)治疗真皮。这种独特的注射方法被作者命名为“微玻尿酸”，这是基于与Microbotox5的类比。作者发明了一种独特的将S-HA与A型肉毒毒素混合的注射溶液，该溶液自2009年以来一直用于皮肤水合和皮肤嫩肤。为了减少产生真皮肿块的风险，使用了增稠化单相HA和自动注射器。作者将微量透明质酸与微肉毒杆菌联合应用。

结果

在50例患者中，用皮肤镜测量细小皱纹的变化，通过经表皮失水和角质层水合水平测量真皮水合程度。

结论

术后4周和8周，经皮失水和角质层水合的变化具有统计学意义。