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Neutralizing antibodies to botulinum neurotoxin type A in aesthetic medicine: five case reports

Sebastian Torres

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简介

【 文献重点摘要 】

 

Botulinum neurotoxin injections are a valuable treatment modality for many therapeutic indications as well as in the aesthetic field for facial rejuvenation. As successful treatment requires repeated injections over a long period of time, secondary resistance to botulinum toxin preparations after repeated injections is an ongoing concern. We report five case studies in which neutralizing antibodies to botulinum toxin type A developed after injection for aesthetic use and resulted in secondary treatment failure. These results add to the growing number of reports in the literature for secondary treatment failure associated with high titers of neutralizing antibodies in the aesthetic field. Clinicians should be aware of this risk and implement injection protocols that minimize resistance development.

 

Keywords

aesthetic medicine, botulinum neurotoxin type A, neutralizing antibody, secondary treatment failure

 

肉毒杆菌神经毒素注射是许多治疗适应症的有价值的治疗方式,也是面部年轻化的美容领域的一种有价值的治疗方式。由于成功的治疗需要长时间的重复注射,重复注射后对肉毒杆菌毒素制剂的继发耐药性是一个持续的问题。我们报告五个案例研究,其中A型肉毒毒素中和抗体在注射美容后产生,并导致二次治疗失败。这些结果增加了越来越多的文献中与美容领域高滴度中和抗体相关的二次治疗失败的报告。临床医生应该意识到这一风险,并实施将耐药性发展降至最低的注射方案。

 

关键词

美容医学,A型肉毒神经毒素,中和抗体,二次治疗失败

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