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【肉毒素文献】咬肌注射A型肉毒毒素后S100和p65表达增加
S100 and p65 expression are increased in
简介
【 文献重点摘要 】
Background: The purpose of this study was to compare the expression levels of p65 and S100 in the rat masseter muscle after the injection of different concentrations of botulinum toxin-A (BTX-A).
Methods: We injected either 5 or 10 U of BTX-A into both masseter muscle of rats. As a control group, the same volume of saline was injected. After 14 days, the animals were sacrificed. Subsequently, a biopsy and immunohistochemical staining of the samples were performed using a p65 or S100 antibody.
Results: The cross-sectional area of each myofibril was significantly reduced by BTX-A injection (P < 0.001). The expression of p65 and S100 increased significantly with increasing concentrations of BTX-A (P < 0.001).
Conclusions: The injection of BTX-A into the masseter muscle induced muscle atrophy. Subsequently, p65 and S100 expression in myoblasts were increased for the protection of muscle cells.
Keywords: Botulinum toxin-A, p65, S100, Apoptosis, Masseter muscle
背景：本研究的目的是比较不同浓度的肉毒毒素-A(BTX-A)注射后大鼠咬肌中p65和S100的表达水平。
方法：大鼠双侧咬肌内分别注射5U和10U的BTX-A。对照组注射等量生理盐水。14天后，处死动物。随后，使用p65或S100抗体对样本进行活检和免疫组织化学染色。
结果：注射BTX-A后各肌原纤维横截面积均明显减小(P<0.001)。随着BTX-A浓度的增加，p65和S100的表达明显增加(P<0.001)。
结论：咬肌内注射BTX-A可引起肌萎缩。随后，p65和S100在成肌细胞中的表达增加，以保护肌细胞。
关键词：肉毒毒素-A，p65，S100，细胞凋亡，咬肌
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