【临床并发症文献】皮肤细菌菌群作为潜在的风险因素
Skin bacterial flora as a potential risk factor
【 文献重点摘要 】
Introduction: Cross-linked hyaluronic acid (HA) gel is widely used in esthetic medicine. Late bacterial infection (LBI) is a rare, but severe complication after HA augmentation. The aim of this study was to determine whether patients who underwent the HA injection procedure and developed LBI had qualitatively different bacterial flora on the skin compared to patients who underwent the procedure without any complications.
Methods: The study group comprised 10 previously healthy women with recently diagnosed, untreated LBI after HA augmentation. The control group comprised 17 healthy women who had a similar amount of HA injected with no complications. To assess the difference between the two groups, their skin flora was cultured from nasal swabs, both before and after antibiotic treatment in the study group.
Results: A significant increase in the incidence of Staphylococcus epidermidis was detected in the control group (P=0.000) compared to the study group. The study group showed a significantly higher incidence of Staphylococcus aureus (P=0.005), Klebsiella pneumoniae (P=0.006), Klebsiella oxytoca (P=0.048), and Staphylococcus haemolyticus (P=0.048) compared to the control group.
Conclusion: The bacterial flora on the skin differed in patients with LBI from the control group. The control group’ s bacterial skin flora was dominated by S. epidermidis. Patients with LBI had a bacterial skin flora dominated by potentially pathogenic bacteria.
Keywords: hyaluronic acid, late bacterial infection, bacterial biofilm, skin bacterial flora, S. epidermidis, S. aureus, Klebsiella spp.
前言:交联透明质酸(HA)凝胶在美容医学中有着广泛的应用。晚期细菌感染(LBI)是HA增强术后罕见但严重的并发症。这项研究的目的是确定接受HA注射程序并发生LBI的患者与接受该程序而没有任何并发症的患者相比,皮肤上的细菌菌群是否有质的不同。
方法:研究组包括10名以前健康的妇女,她们最近被诊断为LBI,在HA增强后未经治疗。对照组包括17名健康女性,她们注射了等量的HA,没有并发症。为了评估两组之间的差异,研究组在抗生素治疗前后从鼻拭子中培养皮肤菌群。
结果:对照组表皮葡萄球菌的发病率明显高于研究组(P=0.000)。研究组金黄色葡萄球菌(P=0.005)、肺炎克雷伯菌(P=0.006)、催产克雷伯菌(P=0.048)、溶血性葡萄球菌(P=0.048)的检出率明显高于对照组。
结论:LBI患者皮肤细菌区系与对照组不同。对照组皮肤细菌菌群以表皮葡萄球菌为主。LBI患者的皮肤细菌菌群以潜在致病菌为主。
关键词:透明质酸,晚期细菌感染,细菌生物被膜,皮肤细菌区系,表皮葡萄球菌,金黄色葡萄球菌,克雷伯氏菌。