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【肉毒素文献】咬肌反复注射肉毒毒素诱导骨改变
Repeated injections of botulinum toxin into the
简介
【 文献重点摘要 】
Objective
To evaluate soft- and hard-tissue changes in the mandibular angle area after the administration of botulinum toxin type A (BoNT-A) injection to patients with masseteric hypertrophy by using three-dimensional cone-beam computed tomography (3D-CBCT).
Methods
Twenty volunteers were randomly divided into two groups of 10 patients. Patients in group I received a single BoNT-A injection in both masseter muscles, while those in group II received two BoNT-A injections in each masseter muscle, with the second injection being administered 4 months after the first one. In both groups, 3D-CBCT was performed before the first injection and 6 months after the first injection.
Results
Masseter muscle thicknesses and cross-sectional areas were significantly reduced in both groups, but the reductions were significantly more substantial in group II than in group I. The intergonial width of the mandibular angle area did not change significantly in either group. However, the bone volume of the mandibular gonial angle area was more significantly reduced in group II than in group I.
Conclusions
The repeated administration of BoNT-A injections may induce bone volume changes in the mandibular angle area.
Keywords
Computed tomography, Soft tissue, Botox, Bony change
目的
应用三维锥束CT(3D-CBCT)评价A型肉毒毒素(BoNT-A)注射治疗咀嚼肌肥大患者后下颌角区软硬组织的变化。
方法
20名志愿者随机分为两组，每组10例。Ⅰ组双侧咬肌一次注射BONT-A，Ⅱ组双侧咬肌注射两次BONT-A，第一次注射后4个月进行第二次注射。两组均在第一次注射前和第一次注射后6个月行3D-CBCT检查。
结果
两组咬肌厚度和横截面积均明显减小，但II组的减小幅度明显大于I组。两组下颌角区的齿间宽度均无明显变化。但Ⅱ组下颌骨性角区的骨体积较Ⅰ组明显减小。
结论
反复注射BONT-A可引起下颌角区骨体积的改变。
关键词
计算机断层扫描、软组织、肉毒杆菌毒素、骨质改变
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