【 文献重点摘要 】
 

Background: Calcium hydroxyapatite (CaHA) is a well-established collagen stimulator. In recent years, it has been increasingly used in hyperdiluted form as a biostimulatory agent rather than a volumizing filler to improve skin quality and firmness in both facial and corporal areas. However, guidelines on the techniques required to achieve optimal results are still lacking. The objective of this study was to develop a consensus recommendation for the safe and effective use of hyperdiluted CaHA for face and body biostimulation.

Methods: A team of 10 experts with extensive experience in dermal fillers and biostimulatory treatments for facial and body rejuvenation convened for a live meeting. Consensus was defined as approval by 70%–89% of all participants, whereas agreement of ≥90% denoted strong consensus.

Results: For most items, the group achieved a majority consensus. Recommendations have been provided for the face, neck, décolletage, buttocks, thighs, arms, abdomen, knees, and elbows with detailed injection techniques, providing information on insertion points, dosages, and volumes for both needle and cannula injections as well as the number of treatment sessions and intervals.

Conclusions: The expert consensus supports and provides guidance for the use of CaHA as a biostimulatory agent for face and body rejuvenation. However, further clinical studies are necessary to provide physicians with the best evidence for the best treatment practices.

背景：羟基磷灰石钙(CaHA)是公认的胶原刺激剂。近年来，它以高度稀释的形式越来越多地被用作生物刺激剂，而不是体积填充剂，以改善面部和躯干区域的皮肤质量和紧实度。然而，关于实现最佳结果所需技术的指导方针仍然缺乏。这项研究的目的是为安全和有效地使用高稀释的CaHA用于面部和身体的生物刺激制定一个一致的建议。

方法：一个由10名专家组成的团队在面部和身体年轻化的真皮填充物和生物刺激治疗方面拥有丰富的经验，他们召开了一次现场会议。共识被定义为70%-89%的参与者同意，而≥的90%的同意表示强烈的共识。

结果：在大多数项目上，小组达成了多数共识。已经为面部、颈部、脱皮、臀部、大腿、手臂、腹部、膝盖和肘部提供了详细的注射技术建议，提供了关于针头和套管注射的插入点、剂量和体积以及治疗次数和间隔的信息。

结论：专家共识支持并指导使用CaHA作为面部和身体年轻化的生物刺激剂。然而，有必要进行进一步的临床研究，为医生提供最佳治疗实践的最佳证据。