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【肉毒素文献】A型肉毒毒素治疗咬肌肥大用于瘦脸

Lower facial remodeling with botox type A for

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【 文献重点摘要 】
 

Background: Masseter hypertrophy has been treated with botulinum toxin injections because of esthetic complaints especially in Asians.

 

Objectives: The goal of the present study was to evaluate the efficacy of abobotulin toxin use in masseter hipertrophy treatment in Brazilians.

 

Methods: Ten Brazilian female patients with masseter hypertrophy were subjected to injections of 90U of abobotulinum toxin A applied on each side respecting the safety zone stabilished in literature and were followed up for 24 weeks.

 

Results: When analyzing the coefficients between measures of middle and lower third of the face obtained from standardized photographs, an increase was observed, with statistical significance at 2 weeks (p=0.005) and 12 weeks (p=0.001). The progression of lower third reduction was 3.94%, 5.26%, 11.99%, and 5.47% (2, 4, 12, and 24 weeks respectively). All patients showed improvement in bruxism after treatment. Observed adverse effects were masticatory fatigue, smile limitation, and smile asymmetry.

 

Conclusion: The use of abobotulinum toxin A for masseter hypertrophy is effective in Brazilians and reached its maximum effect of facial thinning at 12 weeks. Smile limitation had a higher incidence compared to that reported in the literature and may result from risorius muscle blockage caused by toxin dissemination. Despite its side effects, 80% of the patients would like to repeat the treatment.

 

Keywords: Botulinum toxins, type A; Face; Masseter muscle

 

背景:咬肌肥大已经用肉毒杆菌毒素注射治疗过了,特别是在亚洲人中,这是因为他们的审美诉求。

 

目的:本研究的目的是评估巴西人咬肌肥大治疗中使用abobotulin毒素的疗效。

 

方法:10名巴西女性咬肌肥大患者接受90U肉毒杆菌毒素注射,每侧注射一次,注意文献中稳定的安全区,并随访24周。

 

结果:当分析从标准化照片获得的面部中间和下三分之一的测量之间的系数时,观察到增加,在第2周(p=0.005)和第12周(p=0.001)具有统计学意义。下第三次复位的进展分别为3.94%、5.26%、11.99%和5.47%(分别为2、4、12和24周)。所有患者治疗后磨牙症均有改善。观察到的副作用是咀嚼疲劳、微笑受限和微笑不对称。

 

结论:A型肉毒毒素用于巴西人咬肌肥大是有效的,在12周时达到面部变薄的最大效果。与文献报道相比,微笑受限的发生率更高,可能是由毒素传播引起的笑肌阻塞所致。尽管有副作用,80%的病人愿意重复治疗。

 

关键词:A型肉毒毒素;脸;咬肌

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