【 文献重点摘要 】

Retinoids and alpha hydroxy acids differ in mechanism of action for treatment of photodamage, but concurrent use may produce a synergistic effect by combining retinoid-induced normalization of cellular differentiation with alpha hydroxy acid-induced exfoliation (in hydrophilic areas) and enhanced dermal and epidermal hydration. A recent bioengineered molecule, ethyl lactyl retinoate (alpha hydroxy acid retinoid conjugate), is the first to deliver alpha hydroxy acids and retinoids together in a hydrolysis-based time-released fashion. This could improve efficacy while minimizing irritation commonly associated with retinoid use. An eight-week clinical study was conducted to examine the efficacy and tolerability of this formulation; 25 women aged 54.1±8.9 years (mean ± SD) with moderate-to-severe photodamage (as determined by physician investigators using the Glogau Wrinkle Scale) employed a twice-daily regimen of cleanser (7.8% l-lactic acid, 2% salicylic acid) and anti-aging serum (0.1% alpha hydroxy acids-retinoids, 6.5% l-lactic acid) with concurrent use of sun protection factor 50+ sunscreen as needed. Longitudinal analysis of study data revealed statistically significant improvement in photodamage, dryness/flaking, dyschromia, and global appearance at eight weeks. All study products were well-tolerated throughout. Investigators concluded that the alpha hydroxy acid retinoid conjugate is a safe and effective topical therapy for moderate-to-severe photodamage, warranting further study.

维甲酸和α-羟基酸治疗光损伤的作用机制不同，但同时使用可能通过将维甲酸诱导的细胞分化正常化和α-羟基酸诱导的脱落(在亲水性区域)和增强真皮和表皮水合作用结合起来，产生协同效应。最近开发的生物工程分子乳酸乙酯(α-羟基酸-类维A酸共轭化合物)是第一个以水解为基础的时间释放方式将α-羟基酸和类维A酸结合在一起的生物工程分子。这可以提高疗效，同时将通常与使用维甲酸相关的刺激性降至最低。进行了一项为期8周的临床研究，以检验该制剂的有效性和耐受性；25名年龄为54.1±8.9岁(平均±SD)、患有中到重度光损伤(由内科调查人员使用Glogau皱纹量表确定)的女性使用了每天两次的洁面乳(7.8%l-乳酸，2%水杨酸)和抗衰老血清(0.1%α-羟基酸-维甲酸，6.5%l-乳酸)，同时使用防晒因子50+防晒霜。研究数据的纵向分析显示，在8周时，光损伤、干燥/剥落、色泽障碍和大体外观都有统计学上的显著改善。所有研究产品在整个过程中耐受性良好。研究人员得出结论，α-羟基酸类维甲酸结合物是治疗中到重度光损伤的一种安全有效的局部治疗方法，值得进一步研究。