首页 / 国际医美文献/ 皮下填充剂 / 【皮下填充物文献】超声和组织学检查在皮下注射两种增长的透明质酸填充物的初步研究
  • 3389人
  • 分享
    收藏

【皮下填充物文献】超声和组织学检查在皮下注射两种增长的透明质酸填充物的初步研究

Ultrasound and Histologic Examination after

价格 19.90
学习有效期 长期有效

简介

【 文献重点摘要 】

 

Background

This study examined the influence of hyaluronic acid (HA) crosslinking technology on the ultrasound and histologic behavior of HA fillers designed for subcutaneous injection.

 

Methods

One subject received subcutaneous injections of 0.25 ml Cohesive Polydensified Matrix (CPM) and Vycross volumizing HA in tissue scheduled for abdominoplasty by bolus and retrograde fanning techniques. Ultrasound analyses were performed on days 0 and 8 and histologic analyses on days 0 and 21 after injection. A series of simple rheologic tests was also performed.

 

Results

Day 0 ultrasound images after bolus injection showed CPM and Vycross as hypoechogenic papules in the hypodermis. CPM appeared little changed after gentle massage, whereas Vycross appeared more hyperechogenic and diminished in size. Ultrasound images at day 8 were similar. On day 0, both gels appeared less hypoechogenic after retrograde fanning than after bolus injection. Vycross was interspersed with hyperechogenic areas (fibrous septa from the fat network structure) and unlike CPM became almost completely invisible after gentle massage. On day 8, CPM appeared as a hypoechogenic pool and Vycross as a long, thin rod. Day 0 histologic findings confirmed ultrasound results. Day 21 CPM histologic findings showed a discrete inflammatory reaction along the injection row after retrograde fanning. Vycross had a more pronounced inflammatory reaction, particularly after retrograde fanning, with macrophages and giant cells surrounding the implant. Rheologic tests showed CPM to have greater cohesivity and resistance to traction forces than Vycross.

 

Conclusions

CPM HA volumizer appears to maintain greater tissue integrity than Vycross after subcutaneous injection with less inflammatory activity.

 

背景

本研究考察了透明质酸(HA)交联技术对设计用于皮下注射的HA填充物的超声和组织学行为的影响。

 

方法

1例腹部成形术患者,采用团注和逆行扇形技术,皮下注射凝聚增密基质(CPM)0.25ml和Vycross容积HA。分别于注射后第0、8天进行超声检查,并于注射后0、21天进行组织学检查。还进行了一系列简单的流变试验。

 

结果

团注后第0天超声图像显示CPM和Vycross为皮下低回声丘疹。轻柔按摩后CPM变化不大,而Vycross出现更多的高回声,体积变小。第8天的超声图像相似。在第0天,两种凝胶在逆行扇形后似乎比团注后低回声较少。Vycross穿插着高回声区域(脂肪网状结构中的纤维间隔),与CPM不同,轻轻按摩后几乎完全看不见。第8天,CPM呈低回声池,Vycross呈细长杆状。第0天的组织学结果证实了超声结果。第21天CPM组织学结果显示逆行扇形后沿注射行有离散的炎症反应。Vycross有更明显的炎症反应,特别是在逆行扇形后,植入物周围有巨噬细胞和巨细胞。流变试验表明,CPM比Vycross具有更强的粘结性和抗牵引力。

 

结论

CPM HA增容剂在皮下注射后似乎比Vycross保持了更大的组织完整性,炎症活性更低。

题库
暂无绑定的题库哦~

学习目录

学员评价

暂无评价哦~
授课老师

DMCAS学习顾问

资料研究员

猜你想学