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Foreign Body Granulomas after the Use of Dermal Fillers
Lee Jeong Min
简介
【 文献重点摘要 】
A foreign body granuloma is a non-allergic chronic inflammatory reaction that is mainly composed of multinucleated giant cells. Foreign body granulomas may occur after the administration of any dermal filler. Factors such as the volume of the injection, impurities present in the fillers, and the physical properties of fillers affect granuloma formation. The formation of granulomas involves five phases: protein adsorption, macrophage adhesion, macrophage fusion, and crosstalk. The clinical and pathologic features of granulomas vary depending on the type of filler that causes them. Foreign body granulomas can be treated effectively with intralesional corticosteroid injections. Surgical excisions of granulomas tend to be incomplete because granulomas have ill-defined borders and moreover, surgical excisions may leave scars and deformities.
Keywords: Granuloma, foreign-body / Hyaluronic acid / Collagen / Silicone gels
异物肉芽肿是一种主要由多核巨细胞组成的非过敏性慢性炎症反应。异物肉芽肿可能在使用任何真皮填充剂后发生。诸如注射体积、填充物中存在的杂质以及填充物的物理性质等因素影响肉芽肿的形成。肉芽肿的形成包括五个阶段：蛋白吸附、巨噬细胞粘附、巨噬细胞融合和串扰。肉芽肿的临床和病理特征取决于引起它们的填充物的类型。异物肉芽肿可通过病灶内注射皮质类固醇有效治疗。肉芽肿的手术切除往往是不完整的，因为肉芽肿边界不清，而且手术切除可能会留下疤痕和畸形。
关键词：肉芽肿；异物/透明质酸/胶原/硅胶
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