首页 / 国际医美文献/ 皮下填充剂 / 【皮下填充物文献】透明质酸皮肤填充剂的迟发炎症反应
  • 3672人
  • 分享
    收藏

【皮下填充物文献】透明质酸皮肤填充剂的迟发炎症反应

Late-Onset Inflammatory Response to HA

价格 19.90
学习有效期 长期有效

简介

【 文献重点摘要 】

 

Objective

Even though injectable hyaluronic acid (HA)–based fillers are considered safe, rare complications, such as late-onset inflammatory reactions have been reported. Possible causes and effective treatments have not been formally described, so this work aims to discuss these and offer a formal protocol for treatment.

 

Methods

This article presents 5 clinical cases of late-onset inflammatory response occurring at least 3 months after uneventful injection of HA dermal filler.

 

Results

Inflammation appeared spontaneously, usually 4–5 months after the last injection, but in 1 patient, almost 14 months later. One patient was injected at the same time with fillers manufactured by 2 different technologies. In this case, all areas treated with the same filler showed diffuse swelling of inflammatory nature, whereas the lips, treated with the second filler brand, remained unaffected. Four patients reported a flu-like illness or gastrointestinal upset a few days before the onset of dermal filler inflammation.

 

Conclusion

Late-onset inflammatory reactions to HA fillers may be self-limiting but are easily and rapidly treatable with oral steroids, and with hyaluronidase in the case of lumps. It is likely these reactions are due to a Type IV delayed hypersensitivity response. Delayed inflammation associated with HA fillers is nonbrand specific. However, the case where 2 different brands were injected during the same session, but only 1 brand triggered a hypersensitivity reaction, suggests that the technology used in the manufacturing process, and the subsequent differing products of degradation, may have an influence on potential allergic reactions to HA fillers.

 

目的

尽管可注射透明质酸(HA)为基础的填充物被认为是安全的,但也有罕见的并发症,如迟发性炎症反应的报道。可能的原因和有效的治疗还没有正式的描述,所以这项工作的目的是讨论这些,并提供一个正式的治疗方案。

 

方法

本文报告了5例HA真皮填充剂平稳注射后至少3个月出现迟发性炎症反应的临床病例。

 

结果

炎症是自发出现的,通常在最后一次注射后4-5个月出现,但有1例在近14个月后出现。一名患者同时注射了由两种不同技术制造的填充物。在这种情况下,所有使用相同填充物的区域都显示出炎症性质的弥漫性肿胀,而使用第二种填充剂的嘴唇仍然没有受到影响。四名患者在真皮填充物发炎前几天报告了流感样疾病或胃肠道不适。

 

结论

对HA填充物的迟发性炎症反应可能是自限性的,但口服类固醇和透明质酸酶(对于肿块)是容易和快速治疗的。这些反应很可能是由IV型迟发性超敏反应引起的。与HA填充物相关的延迟性炎症是非品牌特异性的。然而,在同一时段注射了2个不同的品牌,但只有1个品牌引发了过敏反应,这表明制造过程中使用的技术以及随后不同的降解产品可能会对HA填充物的潜在过敏反应产生影响。

题库
暂无绑定的题库哦~

学习目录

学员评价

暂无评价哦~
授课老师

DMCAS学习顾问

资料研究员

猜你想学